9ffi. RADIOBIOLOGY FOR. THE RADIOLOGIST. Eric J. Hall, osakeya.info, osakeya.info, F.A.C.R., F.R.C.R.. Higgins Professor of Radiation Biophysics. Professor of Radiation. Eur J Nucl Med Mol Imaging () – DOI /s 8 BOOK REVIEW Eric Hall and Amato J. Giaccia: Radiobiology for the. Library of Congress Cataloging-in-Publication Data. Hall, Eric J. Radiobiology for the radiologist / Eric J. Hall, Amato J. Giaccia.—7th ed. p. ; cm.
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Editorial Reviews. Review. International Journal of Radiation Oncology, Biology, and Physics, Radiobiology for the Radiologist 7th Edition, Kindle Edition. by. Applied Radiation Biology and Radiotherapy Section. International Atomic Fig. Schematic of the electromagnetic spectrum (Hall and Giaccia, ). Radiobiology for the Radiologist. Considered combines traditional and molecular radiation biology principles and appeals to Hall, Eric J.; Giaccia, Amato J.
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Radiobiology for the Radiologist [PDF] 1. Radiobiology for the Radiologist [PDF] 2. Therefore, for clinical use of the LQ model, LQ parameters for tumour should be selected carefully, based on tumour site, histology and the applied LQ model. To account for uncertainties in LQ parameter estimates, exploring a range of values is recommended.
Electronic supplementary material The online version of this article In the early days of radiotherapy it became clear that the biological effect of irradiation was not only determined by the total dose, but also by the characteristics of the treatment schedule such as fraction dose, dose rate and overall treatment time [ 1 ]. Many models have been proposed to predict radiobiological response.
The linear-quadratic LQ model has been best validated by experimental and clinical data, and its conceptual simplicity added to its present popularity in radiotherapy practice, for instance to address clinical problems such as compensation for missed treatment days, comparison of different treatment schemes, and the design of novel treatment schedules in clinical trials [ 2 — 4 ].
Several extensions to the basic LQ model have been developed, particularly to account for incomplete repair [ 5 ] and repopulation [ 6 ]. The LQ model has shown its clinical usefulness in predicting the sparing effect of fractionated radiotherapy, and in comparing the equivalent total dose of different fractionation schedules. Many studies have estimated these radiobiological LQ parameters from clinical data for different tumour sites [ 5 , 8 — 70 ].
Reviews and meta-analyses of multiple fractionation trials have also been published, but only for prostate [ 59 ] and breast cancer [ 33 ].
Therefore, we wish to give a more comprehensive overview of published LQ parameters for all tumour sites and all histologies. Several issues arise when collecting radiobiological parameters of human tumours from the literature.
Some studies have published LQ parameters as a main objective, but reported radiobiological parameters are often hidden in a paper wherein the assessment of a radiobiological parameter had not been the primary goal of a clinical study. Next, different literature values may be reported for the same tumour site, even for the same study population e. Another important challenge is study heterogeneity, which is the variation in LQ parameter values that cannot be explained by chance, i.
Study heterogeneity should not be confused with intratumour and intertumour heterogeneity, which are well known and can be dealt with by explicit modelling of such heterogeneity e. The presence of study heterogeneity indicates that studies are not estimating a single outcome e. Study heterogeneity is a well-known pitfall of literature reviews; the Cochrane Institute recommends to quantify study heterogeneity and explore its origin, rather than to perform a meta-analysis [ 74 ].
Thereby, we wish to provide a guideline for radiation oncologists and radiation researchers to select appropriate radiobiological parameter values for LQ modelling in clinical radiotherapy. The search includes studies indexed until January 24, and was limited to articles in English.
Studies on patients with any tumour were eligible, regardless of tumour site or histology. Intervention needed to have included radiotherapy with photons; no limitations were imposed on the radiation type external beam irradiation, brachytherapy , radiation technique 3D conformal, IMRT, etc.
No limitation was imposed on the clinical endpoint e.